Top 5 Weight Loss Medications That Deliver Results

Top 5 Weight Loss Medications That Deliver Results

Table of Contents

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I. GLP-1 Agonists: The Gold Standard for Weight Loss

II. Cutting Down on Cravings

III. Fat Absorption Blockers and Alternate Pathways

IV. Which Medication Is Right for You

V. Find the Right Medication with ScriptsMD 

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For many people, losing weight goes beyond simple diet changes. Despite best efforts, weight plateaus and rebounds are common without added support. That’s where prescription medications come in. These aren’t quick fixes—they’re medically managed tools that can make long-term weight control more achievable.

This article examines five weight loss prescriptions that have demonstrated strong clinical efficacy. Some are newer, and others have been around for years. Each has its own method of action, approval status, and risk profile. Whether you’re looking for appetite control or metabolic support, understanding your options can help you make the right decision with your doctor.

Quick Takeaways

• Prescription weight loss medications can support meaningful and sustained fat loss.
• Each option comes with different benefits, risks, and eligibility criteria.
• Some medications work by curbing appetite, while others alter how the body stores fat.
• Semaglutide and tirzepatide are leading options with strong clinical data.
• It’s critical to use these treatments under the guidance of a licensed provider.

GLP-1 Agonists — The Gold Standard for Modern Weight Loss

Semaglutide

Sold under brand names such as Wegovy and Ozempic, semaglutide is a GLP-1 receptor agonist that mimics a natural hormone in the body to help regulate appetite. It works by delaying stomach emptying and signaling fullness to the brain, making it easier to reduce food intake. Administered once a week as a subcutaneous injection, it has helped many individuals lose a meaningful amount of weight. When paired with healthy eating habits and physical activity, semaglutide has been shown to produce sustained weight reduction over time.

Tirzepatide

Tirzepatide is a dual-action medication that activates both GLP-1 and GIP receptors. ¹ This combination not only curbs appetite but also supports better blood sugar control. Unlike single-pathway treatments, tirzepatide has demonstrated the ability to trigger more profound weight loss in clinical trials. Patients prescribed this medication often report greater satiety and steady fat reduction. While not yet widely approved for all users, it’s gaining attention as a powerful tool in the next generation of obesity management treatments.

Compounded Alternatives

When brand-name medications are unavailable or too costly, compounded semaglutide or tirzepatide may be a suitable alternative. These versions are created by licensed pharmacies and tailored to meet the individual needs of each patient.

• It requires a valid prescription and should only be filled out by reputable compounding pharmacies.
• It can help patients stay on track during shortages or cost-related barriers, with medical supervision always recommended.

Appetite Suppressants — Cutting Down on Cravings

Phentermine

Phentermine remains one of the most frequently prescribed medications for weight loss nationwide. It works as a stimulant, affecting the central nervous system to help suppress appetite and boost energy levels. ²

Phentermine is typically used as a short-term treatment option. It is typically prescribed to individuals who need rapid results to address pressing health concerns. While not a long-term solution, it can be a useful starting point for those who have struggled to establish a foothold.

However, its stimulant properties mean it must be used with care. Patients often experience increased heart rate or insomnia, so close monitoring by a healthcare provider is necessary during treatment.

Qsymia

Qsymia is a combination of two medications: phentermine, which curbs appetite, and topiramate, a drug initially used to treat seizures and migraines. Together, they work to suppress hunger and support metabolic function, helping patients feel full longer and eat less over time. ³

Here’s how Qsymia typically supports weight loss:

1. Reduces cravings and appetite through central nervous system stimulation.
2. Enhances satiety and reduces binge-eating behaviors.
3. Supports metabolism for sustained fat loss when combined with a balanced diet and regular physical activity.

This medication is typically prescribed to individuals with a higher BMI or those who haven’t seen results from other weight loss strategies. Qsymia can lead to noticeable progress when paired with dietary changes and increased activity.

However, it has potential side effects, including dry mouth, dizziness, and insomnia. It should only be taken under the close supervision of a medical professional. As with all prescription weight loss treatments, success with Qsymia depends on long-term adherence to a doctor-approved plan.

Fat Absorption Blockers and Alternate Pathways

Orlistat

Orlistat is a medication that blocks the absorption of dietary fat by inhibiting the enzyme lipase. When taken with meals, it helps reduce the calories absorbed from fat. ⁴ It is available by prescription and over the counter in a lower dose under various brand names.

While orlistat can support weight loss, it often comes with gastrointestinal side effects, including:

• Oily stools
• Flatulence
• Frequent bowel movements (especially after high-fat meals)

Patients are encouraged to follow a low-fat diet and space out their meals to minimize discomfort. Orlistat is most effective when used in conjunction with lifestyle changes, such as healthier eating habits and regular physical activity. Regular consultation with a healthcare provider ensures the medication remains appropriate and effective.

 

Bupropion/Naltrexone

Known by the brand name Contrave, this medication combines bupropion and naltrexone to help control appetite and reduce food cravings. Unlike traditional stimulants, it targets the hypothalamus and the brain’s reward system, which may minimize impulsive eating behaviors.

Contrave is especially beneficial for individuals who tend to eat in response to emotions or stress. It can help retrain the brain's response to hunger and satisfaction signals, promoting more stable eating patterns.

While effective for some, Contrave may cause side effects, including:

• Nausea
• Headache
• Increased blood pressure

Close medical supervision is essential to ensure that it meets your health needs and goals accurately.

How to Know Which Medication Is Right for You

Matching Medication to Your Health Profile

Not all weight loss medications are effective for every individual. A person’s medical background plays a significant role in determining the best fit for them. Conditions like high blood pressure, diabetes, heart disease, or a history of mood disorders can shape what’s safe or risky. Some medications may worsen symptoms or interfere with other prescriptions. That’s why thoroughly reviewing your health history is essential before starting treatment. Tailoring medication to your profile helps minimize complications and improve long-term outcomes.

The Role of Your Provider

Working closely with a licensed provider is key when starting any prescription weight loss treatment. Your doctor will review your medical history, current medications, and overall goals to recommend the most appropriate option. They’ll also guide you through potential side effects and monitor how your body responds over time.

Regular follow-ups allow you to adjust the plan, ensuring the treatment remains effective and safe. Personalized care leads to better outcomes and helps you stay on track throughout your weight loss journey.

Find the Right Medication with ScriptsMD 

Prescription medications offer a new path forward for people who’ve struggled to lose weight through traditional means. Depending on the body's needs, these treatments can address hunger, metabolism, or fat absorption. Each option has its strengths, risks, and considerations, which is why working with a licensed provider is so important. When used responsibly, these medications help shed pounds and support long-term health and sustainable habits.

If you’re ready to explore your options, contact ScriptsMD to begin your consultation and get personalized guidance today.