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FDA-Approved SSRI for Depression & OCD

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FDA approved since 1991

Learn About Sertraline

What is Sertraline, and How Does it Work?

Sertraline is a prescription medication commonly used to treat major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) in adults. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which are often prescribed for mood-related conditions.

Sertraline works by increasing the levels of serotonin, a neurotransmitter that helps regulate mood, emotion, and sleep. It does this by blocking the reabsorption of serotonin into neurons in the brain, making more serotonin available. This can help alleviate symptoms of depression and anxiety.

How to Take Sertraline

Sertraline is usually taken once daily, either in the morning or evening, with or without food. It’s important to take it at the same time each day to maintain a steady level in your body.

Your doctor will start you on a low dose and may gradually increase it based on your response to the medication. Never change your dose or stop taking sertraline without your doctor’s guidance, as doing so can lead to withdrawal symptoms or a return of symptoms.

Side Effects of Sertraline

Some common side effects include nausea, headache, dizziness, dry mouth, and trouble sleeping. These often improve as your body adjusts to the medication.

Serious side effects are rare but may include severe mood changes, suicidal thoughts, or allergic reactions. Contact your doctor right away if you experience any unusual or severe symptoms.

Sertraline

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How to get Sertraline from ScriptsMD

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Tell us about your medical history, answer a questionnaire specific to your mental health symptoms, and confirm your identity. During this process, we also ask you about your treatment preferences.

A licensed medical professional will assess your history and preferences to create your treatment plan. This usually happens within 24 hours of completing step 1, and our team may contact you for clarifications.

Your treatment ships out in 1-2 days from our partnering pharmacy, directly to your door. Delivery is typically 1 -3 days.

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FDA approved since 1991

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Sertraline: A Proven Medication for Mental Health

Backed by Research, Approved by the FDA

59^%

Of patients taking sertraline reported feeling "better” in 6 weeks

13^%

Greater reduction in depressive symptoms compared to a placebo

40 Million

The number of sertraline prescriptions in the US in 2022

1991

Sertraline was approved in the US in 1991 and is listed on the World Health Organization's List of Essential Medicines

Learn More About Sertraline

Your questions answered

Sertraline is a selective serotonin reuptake inhibitor (SSRI) that is FDA-approved to treat:

Major depressive disorder (MDD) in adults
Obsessive-compulsive disorder (OCD) in adults and children (6+ years)

Sertraline works by stopping nerve cells from pulling serotonin back in, so more of this “feel-good” chemical stays active in your brain. Since serotonin helps manage your mood, personality, and energy levels, keeping it around longer can lift symptoms of major depression.

In clinical trials, participants noticed an improvement in mental health by week 6, with clear improvements in depression showing up around week 12.

Take one capsule daily, with or without food, as directed. Always taper off gradually under supervision to avoid withdrawal.

Like any medication, sertraline may cause side effects in some people. Common side effects include:

Nausea
Diarrhea
Muscle tremor
Indigestion
Decreased appetite
Excessive sweating
Ejaculation issues
Decreased libido

Before starting sertraline, share your full medication list with your doctor. Sertraline can interact with certain medications, such as:

Serotonergic drugs (SSRI, SNRI, triptans): Combining sertraline with these drugs can raise the risk of serotonin syndrome.
Aspirin, NSAIDs, warfarin, anticoagulants, and antiplatelets: Taking sertraline alongside these can increase bleeding risk.

If you are pregnant or planning to become pregnant, let your doctor know. Taking sertraline in the third trimester has been associated with a higher chance of the following in the newborn:

Persistent pulmonary hypertension
Respiratory distress
Temperature instability
Difficulty feeding
Irritability
Decreased muscle tone

Sertraline also passes into breast milk in small amounts. Work with your healthcare provider to weigh the benefits against any potential risks for you and your baby.

Yes. The starting dose of sertraline is usually 150 mg once daily and can be increased to a maximum of 200 mg daily based on how you’re doing. Any dosing changes or discontinuation follow a gradual schedule.

Some people notice changes in appetite when taking sertraline, which can lead to weight shifts. In pediatric studies, children on sertraline lost about 1 kg more than those on placebo.

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FDA approved since 1991