What Are the Most Common Medications in a Weight Loss Prescription?

Table of Contents

II. Appetite Suppressants and Stimulant-Based Options

III. Metabolic Boosters and Combination Prescriptions

IV. What to Know Before You Start a Script

Weight loss doesn’t always start with the gym. For many people, real progress begins with a prescription. More providers are using medication to support healthy, long-term weight goals. These prescriptions aren’t magic pills—but when used carefully, they can make it easier to manage hunger, energy, and overall momentum.

Weight loss scripts are never one-size-fits-all. Your provider reviews your medical history, lifestyle, and any existing medical conditions before determining what to include. The most common medications target appetite, digestion, or how your body stores fat. Understanding what’s typically included—and why—can help you feel more confident during your next telehealth visit.

This article examines the medications that appear most frequently in weight loss scripts. Whether you're just getting started or weighing your options, knowing the basics is a smart first step.

Quick Takeaways

Weight loss scripts often include medications like GLP-1s, appetite suppressants, and metabolic enhancers
Each medication works differently depending on your health profile and goals
Some drugs reduce hunger; others improve how the body uses sugar and fat
Your provider will review your health history before prescribing anything
Side effects vary—understanding them helps you choose the right option
Not every prescription is safe for everyone, even if it's commonly used

Medications and Their Growing Role

How GLP-1s Work Behind the Scenes

GLP-1 medications such as liraglutide and semaglutide help people feel full more quickly. They copy a natural hormone that controls both appetite and blood sugar levels, allowing you to eat less without intense cravings. These drugs slow down digestion, which keeps you feeling satisfied for longer.

Unlike stimulants, GLP-1s do not increase heart rate or energy levels. They help regulate hunger in a steady, natural way. This makes them a popular choice for individuals seeking a long-term solution to weight management. They support your body rather than forcing it to change quickly.

Why They're So Widely Prescribed

GLP-1s are now one of the most common tools doctors use to treat obesity and weight-related conditions. These medications have demonstrated strong results in clinical studies, particularly when patients also make modest lifestyle changes.

The FDA has approved GLP-1s for long-term use in people who meet specific health guidelines. This means more providers feel confident including them in weight loss scripts. They are now considered a reliable option for patients seeking steady, manageable results over time.

A weight loss word map graphic.

What to Watch Out For

Some people experience nausea or stomach issues when starting GLP-1 medications. To help mitigate these effects, most providers begin with a small dose. The goal is to let your body adjust slowly before increasing the amount.

Watch for signs that the medication may not be a good fit:

Ongoing nausea or upset stomach
Signs of thyroid concerns
Digestive issues that get worse over time

These drugs are not suitable for everyone. If you have specific thyroid problems or digestive conditions, your healthcare provider may recommend an alternative option. A comprehensive review of your health history helps them determine what’s safe and effective for your specific needs.

Appetite Suppressants and Stimulant-Based Options

Classic Medications Still in Use

Phentermine has been used for many years to help reduce appetite. It works by affecting signals in the brain that control hunger. Because it can act quickly, providers may recommend it for short-term use when fast results are helpful.

This type of medication is sometimes added to a weight loss script to give early progress a boost. However, it is usually prescribed for only a few weeks. Some people may feel more alert or notice a faster heart rate while using it. These effects are common and are part of the reason doctors closely monitor use. If you have certain heart conditions or sleep disorders, your provider may recommend an alternative option that better suits your needs.

Pros and Precautions

These medications can deliver fast results, especially when someone needs to control cravings early on. Still, they are not suitable for everyone. If you have a heart condition or high blood pressure, your healthcare provider may recommend an alternative option. Some people also experience restlessness or trouble sleeping while using them.

Here are some reasons providers may still choose them:

Quick suppression of intense cravings
Lower cost compared to newer drugs
Flexibility in short-term or transitional use
Easy to combine with other treatments
Useful for early progress before switching plans

Because the effects may lessen over time, these medications are usually prescribed for only a few weeks. Your provider will check in frequently to ensure you're responding well and not experiencing any side effects.

Metabolic Boosters and Combination Prescriptions

Drugs That Support Metabolism

Not every weight loss medication works by reducing hunger—some alter how the body processes energy. One example is topiramate, which may lower binge eating and support better metabolism. It’s often paired with phentermine to strengthen results.

Other medications, like bupropion and naltrexone, target both the mind and body. They may ease emotional eating by balancing mood and appetite. These blends give providers more options when simple hunger control isn’t enough. Each prescription is tailored to your specific needs, particularly if stress or certain habits significantly impact your eating patterns.

When Combinations Are Used

Your script may include more than one medication if your provider believes multiple systems are at play. For example:

A GLP-1 to manage appetite
A mild stimulant for early momentum
A mood-stabilizing medicine to reduce stress eating

Each case is unique, and providers develop plans tailored to your individual history. Combination prescriptions often come with additional guidance and regular check-ins to monitor your response.

What to Know Before You Start a Script

How Providers Choose Medications

Your provider begins by reviewing your health history, current medications, and any known conditions that may be associated with your weight. This helps them understand your unique needs before making any recommendations.

They may also ask about your eating habits, past attempts at weight loss, and the kind of support you’ve had. These details matter. The more they know, the more they can tailor a plan that’s safe and effective for you. Each part of the conversation helps build a script that fits your lifestyle and supports long-term progress.

Making Your Script Work for You

A successful prescription plan depends on your ability to follow it consistently. This includes being aware of potential side effects, taking the correct dose, and consulting with your healthcare provider on a regular basis. These small steps help you stay safe and on track.

Sometimes, your body may react in ways you didn't expect. If anything feels off, your provider can make changes to improve the plan. Let them know how you're feeling and what challenges you're facing. Staying honest and open makes it easier to adjust the treatment so it works better for you.

Get Started with ScriptsMD

Weight loss scripts are more than just a list of pills—they’re tools to help support lasting change. Medications work best when they’re chosen with care and combined with good habits.

Knowing the most common options helps you understand what your provider might suggest and why. Whether it’s a GLP-1, an appetite suppressant, or a metabolic enhancer, the proper script meets you where you are—and helps you move forward safely.

Ready to start your weight loss journey? Contact ScriptsMD today!