Side Effects of Escitalopram: What to Expect from this Antidepressant

Side Effects of Escitalopram: What to Expect from this Antidepressant

Table of Contents


I. Common Side Effects of Escitalopram

II. Serious Side Effects of Escitalopram

i. Serotonin Syndrome

ii. Suicidal Thoughts

III. How to Avoid, Reduce, and Minimize Side Effects

IV. Summary


Escitalopram is a commonly prescribed SSRI (selective serotonin reuptake inhibitor) used to treat depression, anxiety disorders, and related mental health conditions. Like all medications, it can cause side effects. Some of these side effects are mild and temporary, while others are more persistent. 

Although many people tolerate escitalopram well, understanding what to expect can help you feel more in control of your treatment. In this article, we’ll break down the most common side effects of escitalopram, what’s considered normal, and when it might be time to stop escitalopram.

Common Side Effects of Escitalopram

Escitalopram can cause mild side effects, and it’s pretty common to experience these during the first few weeks of starting treatment. As your body adjusts, escitalopram can become better tolerated. 

Common side effects may include:

  • Nausea
  • Headache
  • Dry mouth
  • Increased sweating
  • Fatigue or drowsiness
  • Insomnia or trouble sleeping
  • Decreased libido or sexual dysfunction
  • Dizziness 1

Once your body adjusts to escitalopram, these side effects typically resolve on their own. However, it’s crucial to speak with your healthcare provider if you continue to suffer from these side effects after the initial treatment period.

a woman experiencing insomnia and having a difficult time falling asleepa woman experiencing insomnia and having a difficult time falling asleep

Just because these side effects are common doesn’t mean everyone will experience them. It can be helpful to keep a log or a journal of how your body responds to escitalopram, especially when just starting out. 

Jot down your symptoms, how often they occur, and whether they significantly interfere with your daily life. Check in with your doctor regularly to talk about how you're responding to the medication. These conversations can help fine-tune your dosage and ensure your treatment is as effective as possible.

Serious Side Effects of Escitalopram

Yes, escitalopram is generally well-tolerated by most patients. However, there are some rare but serious side effects to be aware of. One of these is a potential allergic reaction, which may present as a rash, facial or throat swelling, or trouble breathing. If you notice any of these symptoms, seek medical attention immediately.

Serotonin Syndrome

Another possible severe side effect of escitalopram is serotonin syndrome, a rare but potentially life-threatening condition caused by too much serotonin in the body. This can happen if escitalopram is taken alongside other medications that also increase serotonin levels, such as certain antidepressants, migraine treatments, or even over-the-counter supplements. Symptoms of serotonin syndrome may include: 

  • Agitation
  • Confusion
  • Rapid heart rate
  • Muscle twitching or stiffness
  • Heavy sweating
  • Tremors
  • Fever

In severe cases, serotonin syndrome can lead to seizures or loss of consciousness. If you notice any of these symptoms, seek emergency medical care right away.

a woman speaking with her therapist about suicidal thoughts after taking escitalopram

Suicidal Thoughts

In some cases, especially during the early weeks of treatment, escitalopram may increase the risk of suicidal thoughts or behavior. This is most commonly seen when starting the medication or changing the dose. While this side effect is rare, it’s important to take it seriously.

Watch for sudden mood changes, increased irritability, agitation, restlessness, or thoughts of self-harm. Family members and caregivers should also be aware of these signs and report them immediately if noticed. If you or someone you know is experiencing suicidal thoughts, contact your doctor right away or seek emergency help. 

Escitalopram can be highly effective, but monitoring mental health closely, especially in the first few weeks, is a critical part of staying safe and getting the best results from treatment.

How to Avoid, Reduce, and Minimize Side Effects

If you're experiencing side effects with escitalopram, there are several ways to manage them and improve your overall treatment experience.

1. Start Low and Go Slow

To reduce side effects, it’s often helpful to begin with a lower dose of escitalopram and gradually increase it as directed. This gives your body time to adjust and may help avoid common issues like nausea, fatigue, or sleep problems. Never change your dose without checking in with your doctor first.

2. Support Your Body During Adjustment

Simple lifestyle habits can make a difference. Take escitalopram with food to ease stomach upset, stay well-hydrated, and try to maintain a regular sleep schedule. Gentle exercise, reduced alcohol intake, and avoiding new supplements without approval can also help keep side effects manageable.

3. Considering Other Options

If side effects continue to interfere with daily life, your doctor may recommend switching to another antidepressant. One commonly suggested alternative is sertraline, another SSRI that some people find easier to tolerate. To help you understand how the two compare in terms of effectiveness, side effects, and how they’re used, take a look at our breakdown of escitalopram vs sertraline. Finding the right medication can take time, but you're not without options.

Summary

Escitalopram can be a powerful tool for managing anxiety and depression, but like any medication, it may come with side effects. Understanding what’s normal, what to watch out for, and how to manage unwanted symptoms can make the journey feel more manageable. If you ever feel unsure, don’t hesitate to reach out to ScriptsMD for support.

To dive deeper into everything from timelines to tapering, visit ScriptsMD’s escitalopram blog for more clear, helpful content tailored to your treatment journey.